Pimple treatment has traditionally used antibiotics in higher doses and for long periods in an attempt to kill skin bacteria. However, the role of inflammation underlying acne and the importance of settling this in treating and preventing acne is a new field of study. A new biophotonic gel, Kleresca, activated by light, works to reduce skin inflammation and is emerging as a promising alternative to traditional antibiotic and oral vitamin A.
Acne is the most common skin condition which causes significant distress both during the active phases and after pimples settle with post-inflammatory hyperpigmentation and acne scarring.
Acne lesions form when hair follicles become clogged with oil and dead skin cells. This is a perfect environment for overgrowth of bacteria, with Propionibacterium acnes (P. acnes) being the most common pimple-causing bacteria. It was once believed that pimples and cystic acne were a direct result of inflammation from bacterial infections.
Inflammation Causes Pimples.
Inflammation is the central cause of pimples and cystic acne. And this inflammation is seen in the skin even before a pimple develops. Clogged pores develop inflammation as the sebum is rich in enzymes called matrix metalloproteinases (MMP’s) The bacterial infection then adds further inflammation to form a pimple.
Genetic factors, hormones, stress and high glycemic load foods such as sugar and processed (white) carbs bring on zits because they increase oil production and skin cell turnover and leads to sebum-rich blockage in the pores and an environment for P. acnes to blossom.
Treating inflammation not only helps acne settle but can also help prevent it from developing. It is, in fact, the anti-inflammatory effects of certain antibiotics and not its anti-bacterial effects that are of most benefit in settling acne and preventing acne scarring. Some common antibiotics inhibit the overactivity of the matrix metalloproteinases. So pimple treatment needs to focus on settling inflammation.
The Role of MMP’S Pimple Formation and Inflammation?
Matrix metalloproteinases are enzymes that keep the skin healthy by breaking down old and dying skin structures and building new ones. But when they are overactive they cause damage to the oil gland and cellular matrix (collagen-hyaluronic acid-elastin) with the formation of cystic acne and subsequent acne scarring.
As well as the antibiotics, vitamin A (retinoids) may also act by inhibiting the MMP’s.
Will Acne Settle If The Inflammation is Calmed?
Being able to settle the inflammation will settle the acne and help prevent it.
So what is wrong with the current medical approach? It is not addressing the principal cause – the inflammation. Both conventional higher dose, prolonged antibiotics and retinoids have side effects. Oral retinoids may increase the risk of autoimmune diseases, and antibiotics disrupted gut health and contributed to antibiotic-resistant bacteria. Perhaps it is time to rethink pimple treatment.
Kleresca – A New Pimple Treatment.
An alternative pimple treatment without antibiotics or oral retinoids is Kleresca.
Kleresca acne treatment decreases inflammation, normalise cellular activity and address P Acne infection. Kleresca is an entirely new light-based treatment for acne. It is called a biophotonic treatment. Unlike old light-based treatments for acne (which addressed bacteria with blue light, and inflammation with red light therapy), Kleresca involves the application of gel to the acne affected area. The gel, when activated by light, turning the light into a pulsating fluorescent light, that not only kills the bacteria but penetrates deeper into the dermis to reduce inflammation, normalise cell activity and stimulate healthy skin rejuvenation. (reducing acne scar formation.)
It is a more natural alternative for treatment of cystic acne and moderates to severe acne. And because it helps stimulate new collagen and skin rejuvenation it is not only a acne treatment, it also treats acne scarring.
1. Suh DH, Kwon HH. What’s new in the physiopathology of acne. BJD 2015 Jan 24. doi: 10.1111/bjd.13634. [Epub ahead of print]
2. Thielitz, A. & Gollnick, H. Topical retinoids in acne vulgaris: update on efficacy and safety. Am. J. Clin. Dermatol. 9, 369–81 (2008)
3. Antoniou, C. & et al. (in press) A multicenter, randomized, split-face clinical trial evaluating the efficacy and safety of chromophore gel-assisted blue light photo-therapy for the treatment of acne. International Journal of Dermatology.